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Hydromorphone ( sold as Palladone and Dilaudid ) is a more common synonym for dihydromorphinone and dimorphone, commonly a hydrochloride is a potent centrally-acting analgesic medication of the opiate class; it is a derivative of morphine, specifically a hydrogenated ketone therefore a semi-synthetic drug and is both medically an opiate analgesic and legally a narcotic. It should not be confused with hydromorphinol. While all of these are strong opioids, they are indeed different drugs. Additional confusion here comes from the fact that in a handful of countries hydromorphinol is distributed under the trade name Numorphan, which is the trade name for oxymorphone in the rest of the world according to the current version of The A-Z Encyclopaedia of Alcohol & Drug Abuse and other references.

Hydromorphone is notable for its god-like rush that far surpasses heroin in that sense. Though the duration of the high is quite short compared to other opiates.


Pills and Forms

Your typical instant release hydromorphone pill comes in either 2mg, 4mg, or 8mg form. If you are truly lucky and blessed by the opiate gods you may come across pills of hydromorphone that are of higher dosages. These are typically made at the pharmacies themselves and are quite rare to come across unless you know someone who has some form of terminal illness. In slang terms you will mostly hear them referred to as "dillies".

If you're in Canada, you can also find "Hydromorph Contin" - These wonderful lil' capsules are typically priced much lower than Dilaudid tablets and can come in a variety of dosages, some much higher than that of Dilaudid: 3mg, 6mg, 12mg, 24mg and 30mg. The drawback to the Hydromorph Contin is that inside the capsule, you'll find it's in the form of little time-release beads. These beads can be crushed and snorted or IV'd, they're just somewhat of a bitch to crush until you get a technique down (This author generally will crush the beads inside a big metal bowl using a metal ice cream scoop - The most effective way I've come up with yet.)


Hydromorphone is becoming more popular in the treatment of chronic pain in many countries, and it is used as a substitute for heroin and morphine where one or both of these drugs are not marketed. Hydromorphone is preferred even over morphine in many cases ranging from the emergency department to the operating suite to ongoing treatment of chronic pain syndromes on account of hydromorphone's superior solubility and speed of onset and less troublesome side effect profile and lower dependence liability as compared to morphine and heroin. Hydromorphone is thought to be 8-10 times stronger than morphine, but with a lower dependence liability. However other studies have suggested hydromorphone is less than twice as potent as hydrocodone or oxycodone and therefore just over twice as strong as morphine via oral administration.

ROA's and Bioavailability

  • Oral - Taking hydromorphone orally is essentially a waste considering the BA is only 30 - 35%.
  • Intranasal- Is a fairly good ROA considering the BA is about 52.4%.
  • Rectal - The BA is about 33% but it tends to last longer than other ROA's.
  • IV - To get that full on 100% BA from your diluadid IV it and experience it in full force. You will feel like a god.


Dosage as always is subjective to your tolerance to opiate/opioid drugs. Always compare potency to other opiates you normally do to calculate your proper dose. Use your opioid comparison chart like a good smart user. The following table is for newbies and always know that your tolerance to the drug will change through its consumption and it will vary later on.

Dosage Nasal IV
Low 2-4mg 1mg
Medium 6-8mg 2-3mg
High 10-16+ 12mg
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